RNA Details
Disease Name
diabetic cardiomyopathy
Tissue
heart
RNA Symbol
miR-195-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
rattus norvegicus
Detection Methods
NA
Target
Smad7
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
MicroRNA-195-5p Downregulation Inhibits Endothelial Mesenchymal Transition and Myocardial Fibrosis in Diabetic Cardiomyopathy by Targeting Smad7 and Inhibiting Transforming Growth Factor Beta 1-Smads-Snail Pathway
Year
2021
Function
MiR-195-5p downregulation blocked endothelial mesenchymal transition (EndMT) by inhibiting TGF-beta1-smads pathway. Smad7 was the direct target of miR-195-5p and silencing miR-195-5p inhibited EndMT by promoting Smad7 expression.